You could do this with a PodAPI->drop_pod_item() call. If there is a field in your pod you can use to trigger this (don’t forget about the "modified" field), you could do this on one page, otherwise it would be a two-step process: 1) Generate an HTML form of all the items in your pod with a checkbox for each pod item that sends the ID for that line item as the value on submit. 2) A processing pod page as the action for the form that would execute a drop_pod_item() for each id that was selected on the form.
You’re going to want to make sure your action page checks to make sure you are an admin, and debug this thoroughly with a test pod before using it on your live data.